Tag

molecular weight
On the limits of 90° static light scattering for determining weight average molar mass Mw – A discussion with Chief Science Officer, Dr. Wayne Reed Technical Note 003 assesses the fractional error in Mw that results when θ=90° detection is used, instead of a full angular extrapolation via MALS.   Question: Can you compare the differences in...
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Kinetic Analysis of Peptide Aggregation Background Peptide-based pharmaceutical technology requires the delivery of therapeutic oligopeptides as designed in a stable form for effective application. Downstream from therapeutic peptide isolation or synthesis, peptides are often subjected to HPLC purification, synthetic modification, and preparatory treatments for long-term storage. Spoilage in the form of aggregation, degradation or oxidation...
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Fluence Analytics and its academic research partner Tulane PolyRMC collaborated on a peer review article for Polymer Journal which describes the achievement of fully automatic, simultaneous control of polymer composition and molecular weight trajectories during free radical copolymer synthesis. This was accomplished by coupling the continuous ACOMP data stream into a feedback controller which operated pumps for...
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Fluence Analytics and its academic research partner Tulane PolyRMC collaborated on a peer review article for Polymer Journal which describes the achievement of fully automatic, simultaneous control of polymer composition and molecular weight trajectories during free radical copolymer synthesis. This was accomplished by coupling the continuous ACOMP data stream into a feedback controller which operated pumps for...
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Determining Molecular Weight (Mw) and Second Virial Coefficient (B22) of monoclonal antibodies using ARGEN Abstract Protein aggregation is generally believed to occur as the result of two instability factors—  conformational and colloidal. Conformational stability is the difference in free energy between the folded and unfolded states of a protein. Although not directly measured as a...
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Fluence Analytics collaborated with its academic research partner Tulane PolyRMC on a peer review publication in Macromolecular Reaction Engineering. An automatic molecular weight controller is used in semi-batch reactions to produce final polymers that contain distinct subpopulations with different molecular weight distributions (MWD). While blending polymers with different MWD is frequently used to make multimodal polymer products,...
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Fluence Analytics collaborated with its academic research partner Tulane PolyRMC on a peer review publication in Macromolecular Reaction Engineering. An automatic molecular weight controller is used in semi-batch reactions to produce final polymers that contain distinct subpopulations with different molecular weight distributions (MWD). While blending polymers with different MWD is frequently used to make multimodal polymer products,...
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Fluence Analytics and its academic research partner Tulane PolyRMC collaborated on a peer review article for Macromolecules which discusses using ACOMP to automatically control polymer molecular weight during synthesis. The continuous record of monomer and polymer concentrations, Cm and Cp, and cumulative weight-average mass, Mw, furnished by automatic continuous online monitoring of polymerization reactions (ACOMP) has been harnessed...
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Monitoring the effect of initiator concentration on molecular weight and intrinsic viscosity of polyvinyl pyrrolidone (PVP) using ACOMP Abstract Automatic Continuous Online Monitoring of Polymerization Reactions (ACOMP) was used to monitor the free radical polymerization of polyvinyl pyrrolidone (PVP) throughout the reaction. Two batch reactions were run at 1.5% and 2.5% initiator concentration to monitor...
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ACOMP: The Automated System that allows Continuous Realtime Monitoring of Polymerization Reactions Abstract ​ ACOMP (Automatic Continuous Online Monitoring of Polymerization Reactions) is a patented product from Fluence Analytics that continuously monitors and characterizes polymers during polymerization or post-polymerization processing steps of laboratory or industrial scale polymer reactions. Beyond allowing the user to monitor polymerizations...
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